冠心病患者的尿纤维蛋白肽A检测及其临床意义的研究

The Determination of Concentrations of Urinary FPA in Patient s with Coronary Heart Disease and the Study on its Clinical significance

本文应用高效液相色谱法(HPLC)检测了42例正常人,10例稳定型心绞痛、22例不稳定型心纹痛和12例急性心肌梗塞患者的尿纤维蛋白肽A(FPA)的水平,其值分别为2504±10.3ng/mgCr,28.1±13.3ng/mgCr、39.6±11.8ng/mgCr,88.2±28.9ng/mgCr。急性心肌梗塞患者的尿FPA水平明显高于心绞痛患者和正常对照(P<0.01),稳定型心绞痛患者与正常对照的尿FPA水平无显著性差异(P>0.05)。提示冠心病患者体内存在凝血系统的异常,机体处于高凝状态。研究还表明,对冠心病患者的尿FPA水平的检测对冠心病类型的诊断及鉴别诊断有一定的价值,并可通过对尿FPA水平的动态观察评估疗效及预后。

The concentrations of urinary F PA were determinated by High Performance Liquid Chromatograpay ( H PLC ) in 42 healthy individuals, 10 patients with stable angina pectoris( SA P ) , 12 patients with unstable angina pectoris ( UA P ) and 12 patients with acute myocardial infart ion ( AMI ). Its value were 25.4±10.3ng/mgCr, 28.1±13.3ng/mgCr, 39.6±11.8 ng/mgCr and 88.2±28.9ag/mgCr respectively. The concentrations if urinary F PA in patients with AMI were significantly higher than that of healthy individuals ( P<0.01 ) and that of patients with angina pectoris ( P<0.01 )And the concentrations of urinary F PA in patients with UA P were significantly higher than that of patients with SAP. There was no difference between patients with SAP and healthy individuals in concentrations of uritiary F PA( P>0.05) . It showed that there existing abnormal function of coagulation in some pat ients.Their coagulation system were in hypercoagulable state. It also showed that the determination of urinary F PA might be helpful for diagnosis and differential diagnosis of coronary heart disease. And the dynamic determination of urinary F PA might be helpful for evaluating the curative effect and prognosis.