实验性糖尿病大鼠性激素水平及子宫雌激素受体的变化

STUDY ON ESTROGEN RECEPTORS OF UTERUS AND SEXUAL HORMONE LEVELS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

用链脲佐菌素复制了实验性Ⅰ型糖尿病动物模型。给药两周后，实验性ＩＤＤＭ雌性大鼠在动情间期血清雌二醇（Ｅ＿２）水平较对照组降低，雌二醇／睾酮比值下降，推测胞浆雌激素受体（ＥＲ）最大结合容量（Ｂ＿（ｍａｘ））较对照组增高，胞核ＥＲ的Ｂ＿（ｍａｘ）减少。实验结果提示：ＩＤＤＭ雌鼠生殖功能异常可能与Ｅ＿２水平、Ｅ＿２／Ｔ比值降低以及ＥＲ由胞浆向胞核的转移受阻，胞浆滞留有关。

Diabetes was induced in adult female Wistar rats with a single intraperitoneal injection of streptozotocin. The mechanism of reproductive failures was studied in female diabetic rats. Two weeks after using streptozotocin , the result showed that the serum levels of estrodiol (E_2) andthe ratio of serum E_2 to testosterone (T) were significantly lower in diabetic rats than those in controls ; Statistics analysis revealed that the maximal binding capacity (B_(max)) values of cytosol estrogen receptor (ER) were significantly higher in diabetic rats than those in controls and the B_(max) values of nuclear ER were lower. These results indicated that the reprodutive failures of female diabetic rats may have relation to decreased serum levels of E_2 and ratio of serum E_2 to T and nuclear translocation of cytosol receptors.