肺癌BSL＿1受体的表达与临床病理关系的探讨

studies on the Relation between The Expression of BSL1 Receptor andclinical pathology of lung cancer

应用亲合组织化学方法对１９６例原发性肺癌西非单叶豆受体的表达及与各项临床病理指标的关系进行了探讨，结果发现，该受体在肺癌中的阳性率为６２．７６％，质膜上的表达以及胞浆中的表达在肺鳞癌及腺癌中差异均有极显著性（Ｐ＜０．００５，Ｐ＜０．００５）。腔膜上的表达在Ｄ＜３ｃｍ组与其它两组腺癌中差异均具显著性（Ｐ＜０．００５，Ｐ＜０．００５）；质膜阳性率及全阴性率与两组不同生存期鳞癌患者预后的关系均有显著性差异（Ｐ＜０．００５，Ｐ＜０．０２５），提示该受体对肺癌有相对特异性，对揭示肺癌临床病理的生物学行为有一定的作用。

The relations between the expression of BsLl receptor in 196 cases of lung cancer and the feature of clinicaIpathology was studied.The resuIts showed that the positive rate of BSLl-R in lung cancer was 62.76%.The expession ofBsLl-R on poasma membranes between the squamous cell carcinoma and adenocarcinoma was obviously different (p<0.005),so was the expression of BSLl-R in intrapoasma (p<0.005).The expression lined along luminal cells was obviouslydifferent between the adenocarcinoma of d<3cm group and either of another two group(p<0.05,p<0.05);Between the twogroups who lived for over five years and those who died within half a year,the positive rate on plasm membranes was obvious-ly different(p<0.005),so was the negative rate(p<0.25).It is showed that the BSLl-R has relative specificity for humanlung cancer.It is useful for showing the biological behavior of lung cancer.