阿霉素白蛋白微球体内缓释作用及对正常大白鼠栓塞作用的研究

The Effects of Adriamycin Albumin Microspheres of Sustaining Releaseand Embolization of Hepatic Artery on Normal Liver in Rats

本实验对阿霉素白蛋白微球的缓释特性及在正常大白鼠肝内的栓塞作用进行了初步探讨，结果表明：以５０ｍｇ／ｋｇ剂量注入大白鼠肝动脉内，可见肝细小动脉充满栓塞颗粒，肝细胞索呈局灶状坏死；将阿霉素白蛋白微球与阿霉素水溶液实验对照发现前者释药速度明显缓慢，第７小时外周血液浓度达高峰３５．９５ｕｇ／ｍｌ，第２４０小时仍维持在８．０３ｕｇ／ｍｌ，阿霉素水溶液组大白鼠外周血药物浓度仅是“一过性”升高，第０．２５小时达８９．４２ｕｇ／ｍｌ，之后迅速下降，第３０小时接近零，瘤体内直接注入药物，阿霉素白蛋白微球组瘤体局部药物存留量明显高于常规剂型，第４０、１２０小时时前者分别是３２．５２ｕｇ／ｇ和５．８８ｕｇ／ｇ，后者分别是１２．００ｕｇ／ｇ和０。

Experimental hepatic artery embolization and sustain release with adriamycin albumin micro-spheres was performed.The result showed that small hepatic artery was full filled with adriamycin albuminmicrospheres and also observed a lot of necroses of hepatic tissue. Another test told us that adriamycin al-bumin microspheres had the ability of sustain release .After hepatic arterial infusion,the concention of adri-amycin albumin microspheres in peripheral vein blood is 35.95ug/ml at 7hs and lasted until at 240hs. Incontrast,the peak time of drug concentration of infused adriamycin solution appeared at once and de-creased rapidly.The last test quantified content of adriamycin in tumor.The content of adriamycin was 32.52 and 5.88 ug/g respectively in tumor after infusion of adriamycin albumin microspheres at 40 and l20hs.It is superior to the control.The results showed that not only adriamycin albumin microspheres had properlevel of adriamycin in peripheral blood,but also increased content of drug in tumor. Therefore,adriamycinalbumin microspheres could increase index of chemotherapy in patient.