乳腺良恶性肿瘤多项免疫标记检测的意义和相关性探讨

Discusslons on the Signigicance and Relativity of Many Kinds of Immuno-lablling Assay to Benign-Malignant Tumors of Breast.

对１０例乳腺良性肿瘤和４０例乳腺癌进行了Ｃ－ｅｒｂＢ－２，ＥＲ，ＰＲ，ＰＮＡ，ＰＣＮＡ，ＶｉＭ多项免疫标记观察，发现Ｃ－ｅｒｂＢ－２，ＰＮＡ，ＰＣＮＡ，ＶｉＭ在乳腺良恶性肿瘤中阳性表达有明显差异（Ｐ＜０．０５）。在边缘病例中若瘤细胞出现Ｃ－ｃｒｂＢ－２膜阳性，ＰＮＡ，ＰＣＮＡ，ＶｉＭ亦出现阳性，则可作恶性变的可靠指标，在转移和非转移乳腺癌之间Ｃ－ｅｒｂＢ－２，ＰＣＮＡ，ＶｉＭ的阳性表达亦存在着非常显著差异（Ｐ＜０．０１）。它们可作为鉴别乳腺良恶性病变和判断预后的可靠标记物。

Many Kinds of immunolabelling,such as C-erbB-2,ER,PR,PNA.PCNA and ViM wereobserved to 10 cases of benign tumors of breast and 40 cases of breast cancer.It has been found that therewas a significant difference for C-erbB-2,PNA.PCNA and ViM in positive expression hetween henignand malignant tumors(P<0.05).If tumorcells with C-erbB-2positive memhrane in the marginal cases,PNA.PCNA or ViM were also positive,which could be used as a reliable index of malignant lesion.Thepositive cxpression of C-erB-2, PCNA and ViM were present with significant difference hetweenmetastatic and nonmetastatic carcinoma of the breast(P<0.01),which could he used as one term to reli-able index of identify benign and malignant tumors in breast and estimate the prognosi