人肝癌浸润性单核细胞初步观察及其与预后等因素的关系

Pathological Observation Of Tumor Infiltrating Monocytes In 48 Patients With Hepat0cellular Carcinoma

观测经ＨＥ染色的４８例肝细胞性肝癌手术标本石蜡切片中肿瘤浸润性单核细胞的浸润程度，分析了它与预后等因素的关系。结果显示：肿瘤浸润性单核细胞的数量与患者的性别、外周血甲胎蛋白（ＡＦＰ）的水平等无关（Ｐ＞０．０５５）；与患者年龄、ＨＢＶ感染状态、包膜的完整性、肿瘤大小以及肿瘤的坏死程度等有关（Ｐ＜０．０５）；与患者的预后高度相关（Ｐ＜０．０１）。此外，经用肝动脉结扎加插管合并其他疗法（如导向治疗、免疫治疗等）后再手术切除的标本中肿瘤浸润性单核细胞明显多于未经特殊治疗而直接手术者（Ｐ＜０．０１）。上述资料表明：肿瘤浸润性单核细胞的多少受多种因素的影响。

The intensity of tumor infiltrating monocytes(TIM ) were investigated pathologically on tumor tissues、ob-tained from 48 patients with hepatocellular carcinoma(HCC).The results showed the intensity of TIM had no re-lation to sex aand a-fetoprotein(AFP) in peripheral blood of patient(P>0.05);however,was related statistical-ly with age and HBV infection of patients ,and with tumor capsule, tumor size,also with tumor necrosis(p<0.055);and was significantly related with the prognosis of patients after operation(p<0.01).In addition, the intens-ty of TCM from patients who had accepted hepatic arteriaal ligation and hepatic arteriaal infusion(HAL + HAI )and other modalities of treatment such as radiation and immunotherapy was higher than that of those without anytherapies before operation(p<0. 01 ).these data suggest that intensity of TCM be influenced by many factors,which might be of importance for management of HCC if analyzed properly.