三苯氧胺加肝脏灌注治疗中晚期原发性肝癌

Treatment 0f Hepaticellular Carcinoma by Administering tamoxifen and a perfusion of liver With chemicals and/or bio-modulators

本文作者应用荧光组化法对２４例中晚期原发性肝癌进行雌激素受体（ＥｓｔｒｏｇｅｎＲｅｃｅｐｔｏｒ，ＥＲ）检测，对６例ＥＲ阳性的中晚期肝癌，给予三苯氧胺治疗，并配合肝动脉门静脉灌注化疗药物和／或生物制剂，结果ＣＲ１例，ＰＲ３例，ｍＲ１例，ＰＤ１例，总有效率８３％，ＡＦＰ下降４例（６７％），平均生存期９个月。作者认为对肝癌进行ＥＲ检测，对ＥＲ阳性的肝癌病人，采用三苯氧胺加肝脏灌注化疗药物和／或生物制剂的综合治疗措施。

e detected the estrogen receptor of 24 patients with hepaticellular carcinoma with fluo-histochemistry as-say.6 patients with positive estrogen receptor received a treatment by administering tamoxifen and a perfusion ofhepatic arteria and portal vein with chemicals and/or bio-modulators,There were l in CR,3 in PR, 1 in MR and1 in PD;the total effectiveness was 83%;AFP decreased in 4 patients(67%),and their average survival term last-ed 9 months after treatment.These results indicate that the efficacy for treatment of HCC with positive ER wouldbe improved by administering tamoxifen and a perfusion of hepatic arteriaa and portal vein with chemicals and/orbio-modulators