散发性戊型肝炎患者血清抗-HEV的动态观察

Kinetics of Anti-HEV in Sporadic Hepatitis E

对20例急性散发性戊型病毒性肝炎（HE）患者的系列血清，用ELISA检测了抗－HEV，动态观察所见：本组首次采血的最早时间为病程的第5天，最迟为第16天，结果抗－HEV在病后第5日即可检出，第10～30日抗体效价达高峰，30日后随病情好转而逐渐下降，至6个月时94．44％病例已转为阴性，提示血清抗－HEV早期出现，持续时间较为短暂，可作为HE的早期诊断依据。

The serum kinetic of anti-HEV was determined serially by ELISA in 20 cases of acute sporadic hepatitis E. The anti-HEV could be detected as early as 5 days after the onset of the disease, the titer of the antibody reached the peak level within 10-30 days and then gradually declined with the improvement of the illness, At the 6 months after the disease it turned to negative in 94.44% patients. This result indicates that serum anti-HEV appears early in the course and persists for a relatively shoft period of time, Serum anti-HEV assay may be useful for the early diagnosis of hepatitis E.