新生儿先天性巨细胞病毒感染及脑损害的随访研究

Congenital Cytomegalovirus Infection in Neonates and the Follow-up Investigation of Its Brain Impairment

1989年9月至1993年8月4年间，对生后7天内无症状新生儿248例进行了尿中人巨细胞病毒（HCMV）检测。结果尿中HCMV阳性6例，阳性率2．42％。阳性病例随访8个月至4年，尿病毒转阴时间最短3个月，最长1年。检查头颅CT6例，脑干听力诱发电位（BAEP）6例，两者均正常者3例，2例CT提示脑前额顶部轻度萎缩，其中1例伴双侧BAEP异常，1例BAEP异常。另1例则头颅CT正常而右侧BAEP异常。报示无症状性先天性HCMV感染者，可有不同程度脑损伤。

From September, 1989 to August, 1993, the human cytomegalovirus (HCMV) in urine was examined in 248 neonates, within 7 days of birth, who presented no clinical manifestation of the HCMV infection, 6 out of them were positive in the urine HCMV and the positive rate was 2.42%. All the 6 cases were followed up from 8 months to 4 years. the shortest period in which the urine HCMV showed negative was in 3 months and the longest one was in l year. Cranial CT and BAEP. As to other 2 infants, one was abnormal bilatereally in BAEP and another one had abnormal BAEP in right side, showing slight atrophy of frontal-parietal lobe in Cranial CT, and the rest one infant was normal in CT but abnormal in right BAEP. The result of the investigation suggested that these infants who had congenital cytomegalovirus infection but were absent of clinical manifestotion might, to a certain exent, have brain impairment.