摘要
红细胞生成素(erythropoietln,EPO)的研究始于1906年。1957年发现合成EPO的器官是肾脏和1984年重组人EPO的研究成功,使EPO的研究发生了两次质的飞跃。近年来,人们对EPO做了大量的研究,取得了一定的成果。本文根据目前对EPO的研究进展进行综述。
出处
《中国实验血液学杂志》
CAS
CSCD
1995年第4期340-343,共4页
Journal of Experimental Hematology
参考文献17
-
1Costa-Giomi P,Caro J,Weinmann R.Enhancement by hypoxia of human erythropoietin gene transcription in vitro. Journal of Biological Chemistry . 1990
-
2Imai N,Higuchi M,Kawamura A et al.Physicochemical and biological characterization of asialoerythropoietin.Suppressive effects of sialic acid in the expression of biological activity of human erythropoietin ih vitro. European Journal of Biochemistry . 1990
-
3Semenza GL,Nejfelt MK,Chi SM et al.Hypoxia-inducible nuclear factors bind to an enhancer element located 3’ to the human erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America . 1991
-
4Barber DL,D’Andrea AD.The erythropoietin receptor and the molecular basis of signal transduction. Seminars in Hematology . 1992
-
5Beru N,Smith D,Goldwasser E.Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein. Journal of Biological Chemistry . 1990
-
6Mason-Garcia M,Weill CL,Beckman BS.Rapid activation by erythropoietin of protein kinase C in nuclei of erythroid progenitor cells. Biochemical and Biophysical Research Communications . 1990
-
7Koury ST,Bondurant MC,Koury MJ et al.Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood . 1991
-
8Fandrey J,Seydel FP,Siegers CP et al.Role of cytochrome P450 in the control of the production of erythropoietin. Life Sciences . 1990
-
9Yelamarty RV,Miller BA,Scaduto RC et al.Three-dimensional intracellular calcium gradients in single human burst-forming units-erythroid-derived erythroblasts induced by erythropoietin. The Journal of Clinical Investigation . 1990
-
10Blanchard KL,Acquaviva AM,Galson DL et al.Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Molecular and Cellular Biology . 1992
共引文献4
-
1WU Hong Harvey F Lodish(Whitehead Institute for Biomedical Research, Nine Cambridge Center Cambridge MA 02142 USA) (Department of Biology, Massachusetts Institute of Technology Cambridge MA 02139 USA).The Erythropoietin Receptor: Dimerization and Intracellular Signal Transduction[J].中国实验血液学杂志,1996,4(3):229-235. 被引量：4
-
2李美荃,张春勇,安清聪,潘洪彬,陈克嶙,郭荣富.云南乌金猪与约大乌猪低氧适应性的研究[J].畜牧兽医学报,2015,46(6):965-973. 被引量：3
-
3黄仁魏,李铭权,吴祥元,夏忠军,林东军,肖若之.蛋白激酶C在红细胞生成素介导的早期信号转导中的作用[J].中国实验血液学杂志,1997,5(4):378-383. 被引量：2
-
4张晶,黄蕊,郝玲,刘娜.促红细胞生成素对缺氧缺血性脑损伤大鼠的脑保护作用及机制[J].山东医药,2015,55(17):13-16. 被引量：9
-
1晋晓春.红细胞生成素[J].生理科学进展,1995,26(1):73-76. 被引量：4
-
2薇,李晓明,黄日波.人胎肝cDNA中EPO基因的克隆[J].广西农业大学学报,1996,15(1):59-62.
-
3孔德阳,黄智勇,唐杰,郝建兵.促红细胞生成素通过调节未折叠蛋白反应减轻顺铂所致的肾小管上皮细胞凋亡[J].中国病理生理杂志,2014,30(1):133-138. 被引量：3
-
4孙学军,黄俊龙,彭兆云,蒋春雷.低氧诱导因子与氧感受器[J].第二军医大学学报,2004,25(9):1023-1026. 被引量：3
-
5夏桂枝,张国成,陈新民,洪新如.人EPO基因真核表达载体的构建及其在人脐血间充质干细胞中的表达[J].第四军医大学学报,2008,29(6):504-507.
-
6林海泓,罗心平,施海明,龚辉,史益军.促红细胞生成素基因修饰对H_2O_2诱导的小鼠骨髓间充质干细胞凋亡的影响[J].中国分子心脏病学杂志,2015,15(3):1350-1353. 被引量：2
-
7杜玉君,王冠军,杨亮,李秀江.促红细胞生成素对慢性肾衰竭大鼠骨髓红系祖细胞的增殖作用[J].中国药理学通报,2008,24(2):279-280. 被引量：2
-
8免疫分子生物学(免疫化学)[J].国外科技资料目录（医药卫生）,2001(11):28-31.
-
9秦志峰,王小珍.富氧气体对低压缺氧大耳白兔肾EPO基因表达的影响[J].高原医学杂志,2002,12(1):56-56.
-
10邱燕,杜桂芝.氧感受器及其信号转导机制的研究进展[J].国际麻醉学与复苏杂志,2014,35(6):572-576.
