低频重复经颅磁刺激对急性脑梗死后运动功能恢复的影响

Effect of low frequency repetitive transcranial magnetic stimulation on the recovery of motor function in the patients with acute cerebral infarction

目的:探讨低频重复经颅磁刺激(rTMS)对急性脑梗死患者运动功能恢复的疗效。方法:128例急性脑梗死患者随机分入rTMS组和对照组,每组各64例。两组均进行常规药物治疗及康复训练,rTMS组加经颅磁刺激。比较两组治疗前后的运动诱发电位(MEP)、中枢运动传导时间(CMCT)和美国国立卫生研究中风量表(NIHSS)、Fugl-Meyer评分(FMA)、Barthel指数(BI)。结果:治疗后两组MEP、CMCT、NIHSS、FMA、BI较治疗前改善(均P<0.05),rTMS组治疗后优于对照组(均P<0.05)。结论:rTMS可以提高运动神经系统的兴奋性,缩短患者中枢运动传导时间;有助于改善急性脑梗死患者的神经功能缺损,提高患者运动功能和日常生活能力。

Objective： To study the effect of low frequency repetitive transcranial magnetic stimulation（rTMS） on the recovery of motor function in the patients with acute cerebral infarction.Methods： 128 patients with acute stroke were divided into two groups randomly： rTMS group（n=64） and control group（n=64）.Two groups were received routine pharmacotherapy and recovery education.Additional,rTMS group was received low frequency repetitive transcranial magnetic stimulation.Motion evoked potential（MEP）,center motion conduction time（CMCT）,NIHSS score,Fugl-Meyer score（FMA） and Barthel index（BI） of the two groups were compared.Results： After treatment,the MEP,CMCT,NIHSS score,Fugl-Meyer score and Barthel index of both groups were improved（all P0.05）.Compared with control group,the MEP of rTMS group was better,the CMCT,NIHSS score of rTMS group were lower,the Fugl-Meyer score and Barthel index of rTMS group were higher（all P0.05）.Conclusion： Low-rTMS can elevate excitability of motor nervous system,cut down CMCT of the patients.Moreover,Low-rTMS treatment improve neurologic deficits and enhance motor function and activities of daily living of the patients with acute cerebral infarction.