抗CCP抗体与类风湿关节炎临床表现的相关性

Correlation of anti-CCP antibody and the clinical manifestations of rheumatoid arthritis

目的:探讨抗环瓜氨酸肽抗体(抗CCP抗体)与类风湿关节炎(RA)的临床表现的相关性。方法:收录139例RA患者的临床表现及X线分期。以酶联免疫吸附(ELISA)法测定其抗CCP抗体水平,抗类风湿因子(RF)采用乳胶凝集法测定,魏氏法测定血沉(ESR)。结果:抗CCP抗体阳性患者在血沉的分布(阴性vs阳性)、X线分期的分布(Ⅰ+Ⅱ期vsⅢ+Ⅳ期)、关节外表现的分布(<3个vs≥3个)、DAS 28评分的分布(>5.1分vs≤5.1分)方面与抗CCP抗体阴性患者比较,差异均有高度统计学意义(χ2=14.89、6.87、14.63、7.27,均P<0.01)。结论:抗CCP抗体与病情活动的指标(血沉、DAS 28评分)有关,与RA患者关节破坏程度(X线分期)和关节外表现有关。

Objective： To explore the correlation between anti-cyclic citrullinated peptide（CCP） antibody and the clinical manifestations of rheumatoid arthritis（RA）.Methods： 139 patients with RA were evaluated（functional class,joint count,hands X-ray）.Anti-CCP antibody serum titres were measured by the anti-CCP enzyme linked immunosorbent assay（ELISA）.Rheumatoid factor（RF） was detected by latex agglutination.Erythrocyte sedimentation rate was detected by Wen＇s method.Results： There were statistical differences of the ESR positive and negative,Ⅰ＋Ⅱ stage of X ray group and Ⅲ＋Ⅳ,different extra articular manifestations,DAS 285.1 scores and DAS 28≤5.1 scores between the positive anti-CCP antibody group and the negative anti-CCP antibody group（χ2=14.89,6.87,14.63,7.27,all P0.01）.Conclusion： Anti-CCP antibody is correlated with ESR,the disease activity score 28（DAS 28）,stage of X ray and extra articular manifestations in RA patients.