胃癌组织雌激素受体定位及其生物学意义

LOCALIZATION OF ESTROGEN RECEPTORS IN GASTRIC CANCER AND IT'S BIOLOGICAL SIGNIFICANCE

采用免疫组化ABC法对89例胃癌、10例癌旁和11例胃溃疡旁粘膜组织进行了雌激素受体(ER)检测。结果发现:①癌旁和溃疡旁粘膜上皮均为ER阴性,胃癌组织ER阳性率达33.7％,其ER颗粒在细胞内分布呈核型、浆型和核浆型;②胃癌Borrmann Ⅳ型、低分化癌和伴淋巴结转移的胃癌,其ER阳性率明显高于其它类型(P<0.05或P<0.01)。研究表明,ER阳性表达的胃癌与其恶性生物学行为有正相关性。

Using immunohistochemical method, estrogen recptor(ER) was studied in 89 cases of gastric cancer, 10 cases of gastric paracancer mucosas and 11 cases of gastric paraulcer mucosas. The results were found: (1) the epithelium mucosas of paracancer and paraulcer were ER-negative > and ER -postive rate of gastric cancer tissue was 33- 7%. ER-particulates localised in nucleus or cytoplasma, or both nucleus and cytoplasma of cancer cells; (2) the ER postive rates in Herrmann's IV type of gastric cancer, poorly - differentiated cancer and cancer with metastasis to lymph node were significant higher than other types (P<0. 05 P<0. 01). The present study showed that gastric cancer of ER -postive was correlative to it's malignant biologic behavior.