胸腺移植和654—2治疗难治性癫痫的研究

TREATMENT FOR EPILEPSY WITH FETAL THYMIC GRAFT AND 654-2

采用胸腺移植和654—2治疗小儿难治性癫痫45例,总有效率达91.1％,明显高于对照组45.2％(P<0.01)。癫痫患儿T细胞亚群测定与对照组比较显示CD_3、CD_4、CD_4/CD_8明显降低(P<0.01),表明癫痫患儿存在细胞免疫功能异常。胸腺移植和654—2治疗后与治疗前比较CD_3、CD_4、CD_4/CD_8明显升高(P<0.01)可达正常水平,表明其能明显改善癫痫患儿的免疫功能。抗癫痫药物治疗前后各免疫学指标无明显改变,甚至降低,表明抗癫痫药物对患儿T细胞亚群变化无明显影响。

45 children with the epilepsy were treated with the fetal thymic graft and 654-2. Another 42 cases (control group) were treated with the antiepilepsy drugs as usual. It was found that the effective rate of this treatment was 91. 1%, which was very significantly higher than that of the control group(45. 2%),P<0. 01. Compared with the normal children, the counting levels of the T lympholytic subpopulation, such as CD3,CP4 and CD4/CD8, of the patients were remarkably lower (P<0. 01), which indicated that their cytoimmunological function was abnormal. After the patients were treated with the fetal thymtic graft and 654-2, the counting level of CDs ,CD4 and CD4/CD increased obviously (P<0. 01) and reached to the level of the normal group. On the contraries,after the treatment with the anti-epilepsy drugs, these indices decreased instead of increasing. It was considered that the new treatmeat can improve the cytoimmunological fucntion of the patients with the epilepsy and anti-epilepsy drugs don't have any effects on the cytoimmunological function.