消化道肿瘤患者血清甲状腺激素含量、核T_3占据率与甲状腺激素生物效应指标间关系的探讨

ELATIONSP AMONG SERUM T_3 CONCENTRATION ESTIMATED NUCLEAR OCCUPANCY AND BIOLOGOCAL EFFECT OF THYROID

本文采用核T_3占据率(q％)代表血清T_3含量与核T_3受体的饱合程度,探讨消化道肿瘤病人血清T_3含量、q％和甲状腺激素(TH)生物效应指标三者之间关系。结果表明:消化道肿瘤病人血清T_3含量下降,TH生物效应常用指标——血清胆固醇含量变化不大,其原因可能系q％尚在正常范围内,血清T_3含量虽下降但不致引起TH生物效应指标的变化。

We attempted to develop a modal in the patients with carcioma of gastroentestinal tract relating the biological effect of thyroid hormone to serum T3 concentration and the estimated occupancy of nuclear T3 receptors (q%). q% was calclated from the serum T3 CONCENTRATION AND t3 MAA and cholesterol one index of biological effects of thyroid hormone at a tissue level was measuyed. The results showed the serum T3 concentration and % in the patients with the carcinoma were signifi-canthy lower than in the patients with gastroentestitis and normal control group(P>0. 05). The serum cholesterol levels was no difference in all groups. This maybe one of the cause that the patients with the carcinoma had a nomal range of q% .the tissue indices of thyroid hormone action can not be affected by lower serum T3 level.Therefore,the patiento with the carcinoma did not have the clinical symptoms of hypothyrodism in the condition of lower serum T3 concentration .