高原红细胞增多症的病理学观察

PATHOLOGICAL CHANGES OF ALTITUDE POLYCYTHEMIA

本文报道了5例成人高原红细胞增多症尸体解剖材料,总结了本病的临床病理特点和诊断依据,并对其发病理进行了讨论。结果发现:3例合并高原心脏病,4例全身小血管数目增多,2例小血管壁增厚并血栓形成,全身脏器充血、於血及缺氧性损害。高原慢性缺氧是罹患者本病的根本原因。

The pathological changes of 5 autopsies with high altitude polycythemia(HAPC) were studied. AH of these cadavers were male,high altitude (HA) migrators. They were 21 to 44 year old and had lived at HA for 1 to 8 years between 3658 m to 4507 m altitude. The results showed that 3 of 5 cases had been complicated with HA heart disease. 4 ones with the increase of the small blood vessels in their bodies and 2 ones with the thicking of the small blood walls and the formation of thrombus, the congestion, extrayasted blood and anoxic lesion were found in all organs of the bodies. It was considered that the HA chronic anoxia was the primary factor of HAPC. The clinical pathological features, diagnosis and etiology of the disease are discussed.