四逆汤保护小鼠缺血心肌的超微结构观察

Uitrastructural Observation of Protective Effects of Sini Decoction(四逆汤)on Ischemic Myocardium

本实验从心肌超微结构观察了四逆汤对实验性心肌缺血的保护性效应。结果表明:四逆汤显著减少了因心肌缺血而引起的糖原消耗并显著减轻了线粒体的肿胀。提示四逆汤对缺血心肌有一定的保护作用。

The protective effects of Sini Decoction(SD)on experimental myocardial ischemia were studied.Results in- dicated that index for glycogen granules of ischemic myocardium with SD group was higher than that without SD group(11.3±1.8 vs 5.8±1.1.P<0.01).suggesting that SD significantly decreases the ischemia-induced my- ocardial glycogen consumption.In SD group,the mitochondrial specific surface of myocardium was larger than that of the ischemic group(6.33±0.17 vs 5.35±0.26,P<0.01),the mitochondrial volum density of myocardi- um of SD group was lower than that of the ischemic group(33.45±2.71% vs 37.65±1.83%.P<0.05).sug- gesting that SD siginificantly reduced the ischemia-induced mitochondrial swelling.There was no difference in the myofibrii volume density between the two group(P>0.05).It indicated that SD could significantly prevent ischemic injury to myocardium.