丹参和清解Ⅱ号注射液对绞窄性肠管再灌注损伤的保护作用

Injectio Salvia and Qingjie No.2(精解2号)in Protecting Strangulated Intestine in Rabbit from Reperfusion Damage

本实验研究用阻断肠系膜上动、静脉的方法建立家兔绞窄性肠梗阻模型。用自体循环灌注法证明解除绞窄性肠梗阻可引起肠壁再灌注损伤。静脉注射丹参或清解Ⅱ号注射液可明显减轻肠管水肿、粘膜出血、上皮脱落、细胞器及细胞间连接结构破坏,防止肠管自主收缩性减弱和抗爆裂压下降。说明丹参和清解Ⅱ号注射液可在一定程度上保护绞窄肠管形态、结构和功能的再灌注损害。

Although the relief of strangulated intestinal obstruction always causes a typical ischemis reperfusion pro- cess of bowel,surgeons usually paid no attention to strangulated intestinal reperfusion risk and its protection. This experiment using rabbits' strangulated small intestine obstruction model proved that relieving obstruction could cause reperfusion damage,inclding morphologic ultrastructure disconstruction and function lesion.The Chinese medicine,Injectio Salvia and Qingjie No.2.especially the former,could significantly attenuate intestinal edema mucous membrane bleeding,epithelium exfoliation,disruption of the connective tissue between organelle and cells as well as prevent the attenuation of autonomous contractility of intestinal tract and lowering of bursting pressure