养阴方和清解方分别对大鼠肝脏癌变过程影响的组织学观察

Effect of Nourishing-Yin Decoction and Removing-Toxic-Heat Decoction on Histological Observation in Rats Liver during Canceration

本研究应用黄曲霉毒素 B_1(AFB_1)致大鼠肝癌模型,动态观察养阴方和清解方在予 AFB_1同时及癌前病变出现后使用时肝脏的组织学变化。结果发现,养阴方和清解方对 AFB_1所致的肝脏损伤有保护作用;且对 AFB_1所致的肝癌前期病变有明显抑制作用;46周时两中药预防组的肝癌发生率明显低于模型组(P<0.01);在癌前病变出现后用养阴方的养阴治疗组,其肝癌发生率也低于模型组(P<0.05);且各中药组首例肝癌发生的时间明显迟于模型组。

The histological change was observed in rat's liver during canceration,when treatment with Nourishing-Yin Decoction(NYD)and Removing-Toxic-Heat Decoction(RTHD)as well as intake of aflatoxin B_1(AFB_1)diet and after the occurrence of obvious precancerous lesion.The results showed that both decoctions could prevent and inhibit the occurrence of liver damage and precancerous lesion in rat's liver during canceration induced by AFB_1.The incidence rates of hepatocarcinoma in the two prevention groups with NYD and RTHD were marked- ly lower than that in the control group(P<0.05).and in the treated group with NYD was also lower than that in the control group(P<0.05)even after occurrence of the obvious precancerous lesion during the 46th weeks. Moreover,the time for the first hepatocarcinoma occurrence in all NYD and RTHD groups were later than that in the control.