人参健脾丸的药理及毒性研究

Pharmacological and Toxicological Study of Renshen Jianpi Pill(人参健脾丸)

本研究对古方人参健脾丸从消化系统、免疫功能及毒性等方面进行了实验研究。结果表明:本品具有明显增强大鼠胃蛋白酶活性的作用;对利血平引起的小鼠小肠推进功能亢进有明显的抑制作用;能够改善大黄所致脾虚小鼠的脾虚症状,呈现出明显的止泻作用;能明显延长小鼠游泳时间;对可的松致免疫功能低下的小鼠,能够明显增强其腹腔巨噬细胞的吞噬功能;以49.2g 生药/kg 给小鼠灌胃,未见任何毒性反应。此剂量为成人临床用药量的271倍。上述结果提示人参健脾丸的健脾益气,消食和胃作用可能与促进胃肠消化,抑制胃肠运动及增强免疫功能有关。

Experimental studies of Renshen Jianpi Pill (RSJPP) were conducted on digestive system,immunocompe- tence and toxicity.The experimental results showed that:(1) RSJPP enhanced the activity of pepsin in rats by o- ral administration;(2) It inhibited the gastrointestinal hyperactivity induced by reserpine in mice;(3) It relieved diarrhea caused by Rheum palmatum in mice;(4) It extended swimming time in mice;(5) It promoted the corti- sone induced hypo- phagocytosis of peritoneal cavity macrophages in mice;(6) Toxicological test demonstrated no death occurred in mice at oral dose of 49.2 g/kg,which was 271 times that of clinical application.These re- suits suggested that the effects of RSJPP in strengthening the Spleen and tonifying the Qi,promoting digestion and mitigating the stomach might relate to promotion of gastrointestinal digestion,inhibition of its activity and enhancement of immunocompetence.