摘要
复方丹参口服液系由丹参、丹皮组成。该制剂系复方丹参膏的剂型改进品。其0.4g/kg、4g/kg、40g/kg 给小鼠灌服,可使常压缺氧存活时间延长20~38%。该品大、中剂量可明显减少垂体后叶素所致心电图 ST 段上移及 T 波低平;明显缩小结扎动物冠状动脉所致心肌梗塞范围,使梗塞区占心脏比例由28%降为14%、18%;对实验性肾性高血压大鼠有缓慢、温和的降压效应,停药后该作用持续5天以上;可明显拮抗垂体后叶素所致微循环障碍,呈现良好改善微循环作用。实验表明,本品量效反应关系较有规律。本品药效作用稍优于复方丹参膏,但无统计学差异。
Composite Salvia miltiorrhiza oral liquor (CSML) consists of Salvia miltiorrhiza and Paeonia suffroticasa, which is the modification of composite Salvia miltiorrhiza soft extract.After medication of 0.4.4 and 40 g/kg of the drug,the survival time under hypoxia with normal pressure was prolonged for 20-38%.The large and medi- um doses of the drug markedly reduced the pituitary induced ST segment elevation and low flat T wave.They re- duce markedly the area of myocardial infarction by means of ligating coronary artery in rabbits and the proportion of the infarction are in heart from 28% to 14% and 18% respectively.The drug had slow and mild hypotensive effect in rats with experimental renal hypertension.The effect lasted for more than 5 days after withdrew of the drug.The drug antagonized the pituitrin induced microcirculation disorders which showed the effect of improving microcirculation.The data indicted that the dose-dependent effect of the drug was regular and that the effect of CSML was slightly better than that of soft extract with insignificant difference statistically.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1995年第S1期317-319,406,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
复方丹参口服液
抗心肌缺血
降压
Composite Salvia miltiorrhiza Oral Liquor
anti-myocardial ischamic
anti-hypertension