幽门螺杆菌感染与胃癌的相关性初探

RELATIONSHIP BETWEEN HELICOBACTER PYLORI INFECTION AND GASTRIC CANCER

为了研究Ｈｐ感染与胃癌的关系，本文分析了７３例胃癌患者及７３例年龄、性别相匹配的对照组，胃癌组及对照组均经胃镜检查确定。经活检组织的Ｈｐ培养及组织学Ｇｉｅｍｓａ染色，并应用ＥＬＩＳＡ法测定血清抗Ｈｐ抗体水平。结果显示，胃癌组Ｈｐ检出率为５８．９％，血清高水平抗Ｈｐ抗体检出率为６７．１２％，分别与对照组的５３．４２％及５７．５３％比较差异无显著性，两组各年龄段间比较也无差异。胃癌的不同分布部位及不同的组织学类型与Ｈｐ感染无明显相关性。结论，胃癌是一种多因素的疾病，Ｈｐ感染不作为胃癌发生的独立的或必须因素，某些致癌因素可能在某些特殊菌株Ｈｐ感染的基础上或与其共同作用下导致胃粘膜癌变。

In order to assess the relationship between HP infection and gastric carcinoma,The presence of HP with culture and histology(Giemsa staining)and the level of HP serum antibodies(ELISA)were examined in 73 gastric cancer patients and 73 controls matched for age and sex.Patients and controls were selected on referral for gastroscopy.It was shown that the prevalence of HP infection was 58.9% in gastric cancer patients and 53.42% in controls.The high level of serum antibodies were found 67.12% in patients and 57.53% in controls.These differences are not statistically significant.Thereefoe tumor histologic pattern and site of distribution had no efects on the occurrence of HP.Weconclude that gastric cancer is a multifactorial disease,HP infection is not the only necessary factor for gastric carcinogenesis.Some other factors may cause gastric malignancy on basis of some special strain of HP infections.