鼻咽癌P53的表达与癌细胞增殖状态的关系

THE RELATIONSHIP BETWEEN THE EXPRESSION OF P53PROTEN AND THE PROLIFERATING STATUS OFTUMOR CELLS IN NASOPHARYNGEAL CARCINOMA

本实验检测了６３例鼻咽癌（ＮＰＣ）活检标本的Ｐ５３蛋白和增殖细胞核抗原（ＰＣＮＡ）的阳性细胞数量，核仁组成区嗜银蛋白平均数（ＡＧＮＯＲｓ）及丝状分裂细胞数（ＭＣ）。上述４项指标的水平在间变性大的Ａ亚类ＮＰＣ明显高于间变性小的Ｂ亚类（均Ｐ＜０．０５）．表明这４项指标可以作为判断ＮＰＣ恶性程度和估计预后的辅助指标。Ｐ５３蛋白阳性细胞数量和ＰＣＮＡ阳性细胞数量之间呈正相关（Ｐ＜０．０１），这可能是Ｐ５３正常功能丧失，无力阻止ＮＰＣ细胞活跃增生所致。ＰＣＮＡ阳性细胞数量与ＡｇＮＯＲｓ和ＭＣ的水平呈正相关（均Ｐ＜０．０１），提示ＡＧＮＯＲｓ和ＭＣ的水平可能受到ＰＣＮＡ水平的调控。

Abstract The positive cell quantity of P53 protein and PCNA (proliferating cell nuclear antigen) , AgNORs (mean count of nucleolar organizer region - argyrophilia proteins ) and MC ( mitotic count ) were examined in 6 3 biopies of nasopharyngeal carcinoma (NPC). The level of above 4 criteria were higher in group A with more