硒提高肿瘤患者NK细胞和T淋巴细胞功能

THE AUGMENTING EFFECT OF SELENTUM ON NKACTIVITY AND LYMPHOCYTE TRANSFORMATIONIN TUMOR PATIENTS

硒对肿瘤患者细胞免疫功能促进作用的体外试验表明：当亚硒酸钠（Ｎａ２ＳｅＯ３）的作用浓度为４．３４×１０－７ｍｏｌ／Ｌ时，２０例患者淋巴细胞转化明显加强：３Ｈ－ＴｄＲ掺入量由１．０７（±０．５７）ＫＢｑ／１０６淋巴细胞增加到１．５９（±０．７５）Ｋ即／１０５淋巴细胞，Ｐ＜０．０１，同时，硒还显著提高ＮＫ细胞杀伤活性：１４例患者ＮＫ细胞介导的３Ｈ－ＴｄＲ释放率由３０．９７％±１３．９％增至４０．２８％×１３．０１％。Ｐ＜０．０５。提示适宜浓度的硒可能是一种免疫促进剂，硒在免疫功能低下的肿瘤患者的综合治疗中可能具有临床的应用价值。

his article reported the in vitro augmenting effect of selenium on cell-mediated immunity in tumor pa- tients. The lympohcyte transformation and NK cell activity were tested by 3 H-TdR incorporation and release assay. The results showed that sodium selenite ( 4. 34 ×1 0-7. mol /L ) significantly enhanced the lymphocyte transformation in response to PHA , The uptake of 3 H-TdR was elevated from 1 . 07(±0. 57 )kB q /1 06 lym- phocytes to 1.59(±0.75) kB q/106 lymphocytes , P<0. 001. In the presence of sodium selenite (4. 34×10-7 mol/L ) , the NK cell activity also increased markedly : The specific cytotoxic release of 3 H-TdR was elevated from 30. 97%±13. 95% to 40. 28%±13. 01%, P<0. 05. These results suggested that selenium may serve as an agent for improving the immunological activity in tumor patients.