兔胆石性胆囊炎取石前后胆囊形态结构及排空功能的研究

A Study on the Struture and Emptying Function of Gallbladder in Rabbits with Calculous Cholecystitis before and after Cholelithotomy

本实验以人胆固醇结石植入兔胆囊，制作胆石性胆囊炎模型，对取石前后胆囊的形态结构和实时超声显像下胆囊应激ＣＣＫ单次剂量（２．５Ｕ／ｋｇ）的排空功能进行对比研究。结果显示：植石３个月后，实验组胆囊壁呈慢性炎症改变，以炎性渗出为主，胆囊排空功能下降。取石３个月后，胆囊炎症持续存在，但以胶原纤维增生为主，胆囊排空功能不因结石的消除而改善，这可能是非胆囊切除的各种方法治疗胆囊结石后胆石复发的基本病因。

Moddels of calculous cholecystitis was made by implanting cholesterol gallstone from hu-man beings into the gallbadder of rabbits, and the structure of gallbladder wall and gallblad-der emptying resporise to a single dose(2.5u/kg)of CCK-33 with real-time uItrasonographybefore and after cholelithotomy were ultrasonography before and after cholelithotomy were-cornpartively studied. The results showed that :chronic inflammation mainly exudative type,was seen in gallbladder wall of the experimental group three menths after implantation,andthe gallbladder emptying function apparently decreased. Three months after removing thegallstones,cholecystitis remained with proliferation of collagenous fibres,and the impairedgallbladder emptying function could not recover after cholelithotomy. Those are probably theradical causes of gallstone recurrence after various means of noncholecystectomy to managecholelithiasis.