高血压壳核出血甘油和甘露醇脱水治疗效果对比

Comparison of dehydrant effect of glycerol and mannitol on hypertensive putaminal hemorrhage

高血压壳核出血48例患者随机分成3组,按出血量给药,通过定期 CT 扫描,与甘露醇比较,观察病情变化等方法评价甘油脱水效果。甘油纠正脑疝作用不如甘露醇迅速,显著效果在治疗1周之后,无反跳现象。2例出现轻微血红蛋白尿,不影响继续治疗。甘油和甘露醇合用可避免两者的副作用。此外,本文还提示按出血部位及出血量给药可降低死亡率。

48 patients of hypertensive putaminal hemorrhage were randomly divided into three groups. The medichine was administered according to the amount of the bleeding.By the periodical CT scan,the comparison with mannitol action and the observation on symptomatic change,the dehy- drant effect of glycerol was evaluated.The restored action of glycerol on brain hernia was less quicker than mannitol.Therapeutic effect of glycerol became evident a week after administration. There was no phenomenon of rebounding in the duration of treatment.Slight hemoglobinuria ap- pearde in the two cases with no effect on continual treatment.Administration of glycerol associat- ed with mannitol could avoid the side effects of both agents.In addition.it is that the amount of dehydrant agents was decided according to the place and amount of bleeding.Therefore.the mor- tality could be reduced.