HLA-DR抗原在大肠癌组织中的表达

HLA-DR antigen expression in colorectal carci-noma

目的 观察HLA-DR抗原在大肠癌组织中表达及其与临床病理的关系。 方法 用免疫组织化学ABC法检测30例正常大肠组织和92例大肠癌组织中HLA-DR抗原表达。 结果 正常大肠组织无HLA-DR表达,27例大肠癌组织中有HLA-DR表达,阳性率为29.4％。HLA-DR抗原在Dukes'A,B,C期大肠癌的表达率分别为23.5,30.3％和31.0％(P>0.05);HLA-DR抗原在高、中和低分化大肠癌组织中的表达率分别为44.4％,27.4％和28.6％(P>0.05)。 结论 大肠癌组织中有HLA-DR抗原表达,其表达与大肠癌Dukes分期及细胞分化程度无关。

AIMS To study the HLA-DR expression in colorectal carcinoma, and the relation to clinicopathology.METHODS HLA-DR expression was examined in 30 normal colorectal mucosa and 92 colorectal cancers with ABC immunoperox-idase technique.RESULTS The HLA-DR antigen immunostaining was positive in 27 of 92(29.4%) cases, and negative in normal mucosa. In Dukes' A, B and C stages the HLA-DR antigen expressions were 23. 5%, 30. 3% and 31. 0%, respectively (P > 0. 05). In well, moderately, and poorly differentiated colorectal carcinoma the positivity rates were 44. 4%, 27.4% and 28.6%, respectively (P >0.05).CONCLUSIONS There is the expression of HLA-DR antigen in colorectal carcinoma, and the expression of HLA-DR antigen has no relation to Dukes' stage and tumor differentiation.