银杏叶总黄酮苷毒理学和药效学研究

Studies on toxicity and pharmacologic effects of total flavonoid of ginkgo

银杏叶总黄酮苷致突变实验显示：对Ａｍｅｓ、ＭＮ实验为阴性，对ＣＡ为可疑阳性；４０％６０ｍｇ·ｋｇ－１ＴＦＧ对ＮａＮＯ２、异丙肾上腺素引发动物缺氧有明显耐受，延长常压耐缺氧实验动物存活时间，拮抗＂血瘀型＂动物血液流变学改变；病理学检查显示对老年动物心肌萎缩变性和血管硬化有改善作用，增加神经细胞和毛细血管壁对缺氧耐受能力，提示药效作用机理可能是扩张血管，改善局部血供应。

Total flavonoid of ginkgo (TFG) was negative to Amestest and MN test, and doubtfully positive to CA test of CHL cell strain. 40% 60 mg· kg-1 TFG induced obvious endurance to the anoxygen evoked by NaNO2 and Isoprenaline. Suvival time of animal were lengthened on nature pressure endurance anoxygen test. The change of hemorheology for blood-extravasated animals were inhibited. Pathologic examination showed that atrophy and degeneration of heart muscle and vascular sclerosis were improved in old animals. Endurance ability to anoxygen was increaced in neurons and capillaries. These results suggest that pharmacologic effect of TFG might be to expand blood vessels and improve local blood flow.