纯化肿瘤坏死因子对正常兔的多器官损害作用

THE DAMAGE EFFECT OF PURE TUMOR NECROSIS FACTOR ON THE NORMAL ORGANS OF RABBITS

将健康日本大耳家兔１８只随机分为实验组８只和对照组１０只。实验组每只静脉注射纯化的免肿瘤坏死因子０．５ｍｇ／ｋｇ。结果显示：实验组动物出现类似内毒素引起的症状，各主要器官功能受到明显损害，血压降低，各主要器官重量比也明显升高，其病理形态学改变与多器官衰竭模型相似，大部分动物于实验结束前死亡。与对照组相比，上述各项检测指标均有显著性差异（Ｐ＜０．０５）。提示纯化的肿瘤坏死因子可引起兔多器官损害。

The damage effects of the pure tumor necrosis factor (TNF) on the normal animals were observed. Eighteen rabbits were divided into two groups, eight in tested group and ten in control group.0.5mg per kg of the pure rabbit TNF was given to each animal of the tested group. Results: The symp toms similar to that induced by endotoxin appeared after the TNF injection. The functions of the main organs were markedly damaged. The arterial blood pressure of most animals was low. The weight ratio of the organ to the body was raised. The pathologic changes were similar to those of the multiple organ failure (MOF) model. Most of the animals died before the end of the experiment. The results suggest that pure TNF could induce multiple organ damages similar to those of MOF.