胃粘膜保护方治疗消化性溃疡80例临床及实验研究

Gastric mucosa - protective recipe weibaofang in the treatment of 80 cases of peptic ulcer and its experimental study

目的:本文旨在研究胃粘膜保护方对消化性溃疡的疗效及机制。方法:经胃镜证实的消化性溃疡患者80例随序给予该方(胃溃疡12例,十二指肠溃疡28例)或甲氰咪胍(胃溃疡10例,十二指肠溃疡30例)对照治疗,8周后胃镜复查,进行比较,并随访1年。实验动物为Wistar大鼠,每组各12只。分别观察对无水乙醇所致胃粘膜损的疗效,对胃酸、胃粘膜及PGE_2的影响。结果:该方组溃疡愈合率(75.0％)与对照组(70.0％)相似,而Hp清除率(55.0％和22.0％)、胃窦炎好转率(50.0％和15.0％)和溃疡1年复发率(35.7％和82.1％)均优于对照组。动物实验表明该方对无水乙醇所致胃粘膜损伤具有保护作用(损伤指数13.8±13.0比75.0±33.0％)。机制与促进胃粘液分泌有关。结论:胃保方治疗消化性溃疡有效,能促进胃粘液分泌,复发率较甲氰咪胍低。

AIM The effects and mechinisms of gastric mucosa protective recipe weibaofang on peptic ulcer were studied. METHODS Eighty patients with peptic ulcer diagnosiscd endoscopically were treated by weibaofang)gastric ulcer 12 patients,duodenal ulcer 28 patients)or cimetidine)gastric ulcer 10 patients,duodenal ulcer 30 patients)at randomized and reexamined and compared 8 weeks late,then followed up for 1 year.The protective effects on enthol induced gastric lesion,the effects on gastric acid,gastric mucus secretion and gastric mucosa PGE2 were studied in Wistar rats)twelve rats in each group).RESULTS The healing rat of peptic ulcer in study group was 75.0% which was compared with the rate in control group 70.0%)P>0.05),but the clearance rate of helicobacter pylori)55.0% vs.22.0%),the improvement rate of antral gastritis)50.0% vs.15.0%)and ulcer relapse during 1 year)35.7% vs.82.1%)were significantly better than those in control group.This recipe can protect gastric damages from enthol)lesion index 13.8 ±13.0 vs.75.0 ±33.0 P<0.05)and its protective mechinism may be related to the increase of gastric mucus secretion.CONCLUSION Weibaofang can increase the gastric mucus secretion and has an effect on peptic ulcer and lower ulcer relapse.