孕产妇及胎儿血浆儿茶酚胺水平的研究

Study on detecting plasma catecholamine levels in fetuses and pregnant women

采用高效液相色谱层析技术，检测了７８例孕产妇、９例非孕妇女、６０例脐血的血浆儿茶酚胺（ＣＡ）水平。结果表明，在孕期除去甲肾上腺素明显降低外，各组间ＣＡ水平无明显变化；脐动脉ＣＡ明显高于脐静脉（Ｐ＜０．０１）；剖宫产组脐血浆ＣＡ水平明显低于阴道产组（Ｐ＜０．０１）；胎儿窘迫的脐血浆ＣＡ水平明显增高，其幅度与新生儿窒息的发病率有关。作者认为胎儿血浆ＣＡ水平产生于自身，并非母体所传递；胎儿窘迫ＣＡ升高，可做为早期诊断胎儿窘迫及其严重程度的一项辅助指标。

This paper reported that plasma catecholamine(CA) levels were determined using High-Perfor-mance Liquid Chromatography (HPLC) in 78 cases of pregnant women, 9 cases of non-pregnant women, 60 cases of fetuses. The results indicated that plasma norepinephrine(NE) levels of pregnant women decreased with advance of gestational week, but plasma epinephrine(E) and dopamine(DA) levels had no-significant difference in gestational period; plasma CA leveis of umbilical artery were higher than that of umbilical vein in the normal infants who born from vaginal delivery(P<0.01 ) ;in fetal distress umbilical plasma CA levels increased significantly,degree of increase related with incidence of fetal asphyxia. This indicates that plasma CA levels of fetuses may be produced from themselves; and that the increase of plasma CA levels in fetal distrese may be a reference index for diagnosing fetal distress and its serious degree.