顺铂和放射治疗联合应用治疗晚期鼻咽癌的临床研究

COMBINEDRADIOTHERAPY AND CISPLATIN FOR ADVANCED NASOPHARYNGEAL CARCINOMA

为探索顺铂和放疗联合治疗鼻咽癌的协同作用，对６０例Ⅲ、Ⅳ期鼻咽癌患者进行了随机对照试验，３０例采用顺铂加放疗（实验组），３０例单纯放疗（对照组）。两组的放疗方法及照射剂量相同。实验组加用顺铂３０ｍｇ，每周１次，共６～７次。初步结果显示，实验组原发灶及颈结的肿瘤消退剂量均低于对照组（Ｐ＜０．０５）。颈转移灶的疗终残存率两组分别为１０．３％（３／２９）和３４．５％（１０／２９），Ｐ＜０．０５。原发灶的残存率两组无明显差异（Ｐ＞０．０５）。表明顺铂起放射增敏剂作用，适当给予可能有助于改善放疗效果，降低复发率。

AbstractA prospective randomized clinical trial in patients with Stage III or IV nasopharyngeal carci-noma was carried out to evaluate the radiosensitizing effect of cisplatin(DDP);Between 1990 and1992, 60 patients were treated: 30 by conventional radiotherapy alone(control group)and 30 bycombination of DDP with radiotherapy(study group). DDP 30mg was given on the first day ofevery week during the radiation course。 The total cumulative dose of DDP veried from 180-210mg。 Preliminary results showed that radiation was needed for treatment of the primary lesion andthe cervical metastasis was lower in the study group than in the control group(P<0. 05)。 At theend of treatment, the residual rates of the neck lesion were 10.3%in study group and 34.5%incontrol group(P<0. 05)。This study may imply that rational administration of cisplatin could im-prove the treatment result.