鼻咽癌放疗后听觉诱发电位的变化

BRAIN STEM AUDITORY EVOKED POTENTIALS IN RADIATED PATIENT WITH NASOPHARYNGEAL CARCINOMA

放疗是鼻咽癌（ＮＰＣ）的主要治疗手段。但是，大脑颞叶，脑干等也包括在常规照射野内，由此可能造成的放射性脑病是一种严重的后遗症，目前尚无客观的早期预测及检测方法。１９９２年９月至１９９３年６月，我们检测了１６例ＮＰＣ放疗后３～２６个月病人的听觉脑干电反应（ＡＢＲ），中潜伏期听觉电反应（ＭＬＲ）和皮层慢反应（ＳＶＲ）。在ＡＢＲ中，表现为各波峰潜伏期延长，Ⅰ－Ⅴ波峰间潜伏期延长，３例被确定为脑干功能异常；ＭＬＲ和ＳＶＲ未见明显异常。ＡＢＲ可作为预测放射性损害的客观指标之一，有助于放疗后有症状病人的鉴别诊断和对复发病人治疗方案的选择。

AbstractRadiotherapy is the main treatment of nasopharyngeal carcinoma(NPC). The auditorycortex and brain stem are often located within radiation fields that may result inradionecrosis of brain which is rare but a serious complication. There is still no forecastingor early detecting method yet.From September, 1992 to June, 1993, brain stem auditoryevoked potential(BAEP)was recorded in 16 NPC patients irradiated 3-26 months earlier. Inauditory brain stem response(ABR) test, some patients had delay of waves and prolongationof wave Ⅰ-Ⅳ lafency interval, and 3 patients were found to have damage of brain stem. ABRcan be one of indexes for radiation-induced damage,which would hlep in the differentialdiagnosis and facilitate a rational method of treatment.