35MeVp→Be快中子分次照射猪皮肤晚期损伤的实验研究

THE LATE DAMAGE IN PIG SKIN TO FRACTIONATED DOSES OF 35 MEV P-BE FAST NEUTRON IRRADIATION

３５ＭｅＶＰ→Ｂｅ快中子分次照射猪皮肤的晚期损伤，４个剂量组分别为１９．８ｎＧｙ、２２．２ｎＧｙ、２４．６ｎＧｙ、２７０ｎＧｙ，６周内分１２次照射，晚期皮肤损伤的平均潜伏期分别为１７．００周、１３．６７周、１４．００周及１７．００周（Ｐ＞０．０５），其ＥＤ＿（５０）为２１．０ｎＧｙ。晚期损伤潜伏期与总剂量无关；晚期损伤发生几率与总剂量相关。猪皮肤晚期损伤的特征是在紫黑色红斑基础上发展为皮肤坏死，颇难愈合。

AbstractThe late damage in pig skin to fractionated doses of 35 Mev fast neutron wasstudied.Neutron fractionation scheme comprised of 12 fractions in 42 days.Thelatent period of late damage of 19.8, 22.2, 24.6 and 27.0 nGy groups were 17.00 ± 1.53, 13.67 ± 1.45, 14.00 ± 2.31 and 17,00 ± 2.00 weeks, respectively(p >0.05).The ED50value for late damage was 21.0 nGy.The mean latency of late pig skin damage wasnot related to the total dose. However,the incidence of late damage was relatedto the total dose. The late damage in pig skin was characterized by a dusky/mauveerythema which could progress to dermal necrosis.The mean latency for the deve-lopment of necrosis was longer and it was harder to heal than the pig skin earlyreaction.