谷胱甘肽硫转移酶（GST－π）的肝内定位意义及与γ－GT、AFP的比较

SIGNIFICANCE OF GST-π LOCALIZATION IN LIVER TISSUES IN COMPARISION WITH γ-GT AND AFP

本文对各种肝病肝组织内人胎盘型谷胱甘肽硫转移酶（ＧＳＴ）作免疫组化定位检测，并与γ－谷胺酰转肽酶（γ－ＧＴ）、甲胎蛋白（ＡＦＰ）作比较，发现肝癌组及慢性肝病组内ＧＳＴ－π检出率分别为２１／２２，９５．４５％和９／１３，６９．２３％，均高于γ－ＧＴ（７７．２７％和３０．７％）以及ＡＦＰ（７２．７３％和７．６９％），而非肝病对照组为０。ＧＳＴ－π在肝癌之癌内、外组织检出率均高，但γ－ＧＴ以癌外为高，ＡＦＰ以癌内为高，结果表明ＧＳＴ－π作为肝细胞癌的标志，其敏感性高于ＡＦＰ和γ－ＧＴ。文内还讨论了ＧＳＴ－π在慢性肝病中检出的意义。

Human placenta form of glutathione s-transferase (GST--π), in comparision with γ-glutamyl transpeptidase (γ--GT) and α--Fetoprotein (AFP) was immunohistochemically located in liver tissues from varied hepatic disaases.PesiPivo trates of GST-π were 95. 45% (21/22)in Hepatocellular Carcinoma (HCC) group and 69,23%(9/13)in Chronic Liver Diseases (CLD) group, they were higher than those of γ--GT and AFP, but negative in control group (without any hepatic lesions). GST-π could be detected highly both inside and outside the cancerous areas in HCC group, however γ--GT was higher outside and AFP vise versa. The resutls suggested that GST--π was a more sensitive marker for HCC compared with AFP or γ-GT. The significance of GST--π in CLD was also discussed.