摘要
应用免疫组化技术亲和组化法和ABC法,检测了106例乳腺癌组织中ER、PR和CEA水平。其阳性率依次为83%、81.1%和88.7%。其中79.2%的乳腺癌ER和PR表达一致。在98例ER和/或PR阳性乳腺癌中有92例(93.9%)呈CEA阳性,8例ER和PR阴性乳腺癌中6例(75%)为CEA阴性,89%乳腺癌CEA与ER和PR表达一致。在癌的分级表达中,随着癌的组织学分级增高CEA阳性率增高,而ER和PR阳性率减低。结果表明,乳腺癌ER、PR和ChA表达可反映肿瘤的不同生物学特征。同时检测三者对选择内分泌治疗及判断预后更有意义。
cases of primary breast earcinoma Were assayed for estrogen and progesterone receptors and. carcinoembryonic antigen (CEA) with bistochemical and ABC immunohistochemicalmethods. The results showed that the positive rates of ER, PR and CEA were 83%, 81. 1%and 80. 7% respectively. In 79. 2% of breast carcinoma, the.expression of ER was uniformwith PR, and in 89%, CEA expression was in accordance with ER and PR: The positive rateof CEA increased with progressing pathologic stage. But there were significant inverse relations between steroid receptors and pathologic stage. Therefore, steroid receptors and CEAappear to provide information about different biologic characteristics of a carcinoma. Furthermore, simultaneous assying of ER. PR and CEA may have greater significance for selecting endocrine therapy and evaluating prognosis.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
1994年第3期293-295,共3页
Chinese Journal of Histochemistry and Cytochemistry