乳腺癌组织中ER、PR和CEA相关性研究

A RELATIVE STUDY OF CARCINOEMBRYONIC ANTIGEN AND STEROID RECEPTORS IN BREAST CARCINOMA

应用免疫组化技术亲和组化法和ＡＢＣ法，检测了１０６例乳腺癌组织中ＥＲ、ＰＲ和ＣＥＡ水平。其阳性率依次为８３％、８１．１％和８８．７％。其中７９．２％的乳腺癌ＥＲ和ＰＲ表达一致。在９８例ＥＲ和／或ＰＲ阳性乳腺癌中有９２例（９３．９％）呈ＣＥＡ阳性，８例ＥＲ和ＰＲ阴性乳腺癌中６例（７５％）为ＣＥＡ阴性，８９％乳腺癌ＣＥＡ与ＥＲ和ＰＲ表达一致。在癌的分级表达中，随着癌的组织学分级增高ＣＥＡ阳性率增高，而ＥＲ和ＰＲ阳性率减低。结果表明，乳腺癌ＥＲ、ＰＲ和ＣｈＡ表达可反映肿瘤的不同生物学特征。同时检测三者对选择内分泌治疗及判断预后更有意义。

cases of primary breast earcinoma Were assayed for estrogen and progesterone receptors and. carcinoembryonic antigen (CEA) with bistochemical and ABC immunohistochemicalmethods. The results showed that the positive rates of ER, PR and CEA were 83%, 81. 1%and 80. 7% respectively. In 79. 2% of breast carcinoma, the.expression of ER was uniformwith PR, and in 89%, CEA expression was in accordance with ER and PR: The positive rateof CEA increased with progressing pathologic stage. But there were significant inverse relations between steroid receptors and pathologic stage. Therefore, steroid receptors and CEAappear to provide information about different biologic characteristics of a carcinoma. Furthermore, simultaneous assying of ER. PR and CEA may have greater significance for selecting endocrine therapy and evaluating prognosis.