大肠癌细胞核DNA含量与预后关系的研究

STUDY ON NUCLEAR DNA CONTENT OF COLORECTAL CARCINOMA AND ITS PROGNOSTIC SIGNIFICANCE

本文应用显微分光光度计(microspectro photometer,MSPM)对38例大肠癌胞核DNA含量进行了测定。结果显示各型大肠癌与正常粘膜对照间,胞核DNA含量相差非常显著(P<0.01);高、中、低分化腺癌DNA含量呈梯形增加,各组间相差非常显著(P<0.01),而高分化腺癌和粘液腺癌间无显著差异(P>0.05)。随着癌细胞核DNA含量增加,非倍体数增加,其5年生存率逐渐下降,而肿瘤复发和死亡率逐渐增高。表明胞核DNA含量测定可作为大肠癌分级、判断预后的参考指标。

Nuclear DNA content in 38 specimens of colorecttal carcinoma was quantitive-ly determined with microspectrophotometer(MSPM). The results indicated that there were very significant differences of the DNA content among various types of carcinoma and normal mucosa (P<0.01), and also among different types of tubular adenocarcinoma (P<0.01), but there was no significant difference of the DNA content between differentiated well adenocarcinoma and mucious adenocaroinoma(P>0.05). With nuclear DNA content increasing, the five year survival rate of the diseases decreased and the aneuploid, the recurrence rate and the mortality increased. These suggested that the DNA content of colorectal carcinoma maybe be used as an objective index of prognosis.