摘要
A precursor of sarcophytol-Q, (11 S) -3, 7, 11, 15-tetramethyl-11-hydroxy-14-oxo-3E, 7E, 12E-hexadecatrienal, was synthesized by a convergent and stereoselective manner from geraniol via nine steps employing asymmetric Sharpless epoxidation and be (n-BuLi)-induce dehydrohalogenation rearrangement of chiral epoxy chloride (4) and the phase transfer catalytic coupling reaction of allylic phenyl sulfone (9) with chiral allylic chloride (6) as key steps.
A precursor of sarcophytol-Q, (11 S) -3, 7, 11, 15-tetramethyl-11-hydroxy-14-oxo-3E, 7E, 12E-hexadecatrienal, was synthesized by a convergent and stereoselective manner from geraniol via nine steps employing asymmetric Sharpless epoxidation and be (n-BuLi)-induce dehydrohalogenation rearrangement of chiral epoxy chloride (4) and the phase transfer catalytic coupling reaction of allylic phenyl sulfone (9) with chiral allylic chloride (6) as key steps.
