摘要
The intermediary perfluoroalkyl radical generated from the reaction of perfluoroalkyl iodide with sodium dithionite was shown to be reactive toward tyrosine esters, resulted in the formation of meta-substituted products which can be transformed into the corresponding amino acids after removal of the carboxyl Protected groups of the esters. Thus, the reaction provides a novel method to introduce a perfluoroalkyl group into the aromatic ring of tyrosine in the meta-position.
The intermediary perfluoroalkyl radical generated from the reaction of perfluoroalkyl iodide with sodium dithionite was shown to be reactive toward tyrosine esters, resulted in the formation of meta-substituted products which can be transformed into the corresponding amino acids after removal of the carboxyl Protected groups of the esters. Thus, the reaction provides a novel method to introduce a perfluoroalkyl group into the aromatic ring of tyrosine in the meta-position.
