摘要
Huperzine A (1), a new Lycopodium alkaloid isolated from Chinese traditional medicine Huperzia Serrata, is a potent acetylcholinesterase inhibitor and a promising drug candidate of treating Alzheimer's disease as well. Several analogues of huperzine A, compound 8, 10, 14, 15 and 17were prepared and their inhibitory activities of acetylcholinesterase were evaluated
Huperzine A (1), a new Lycopodium alkaloid isolated from Chinese traditional medicine Huperzia Serrata, is a potent acetylcholinesterase inhibitor and a promising drug candidate of treating Alzheimer's disease as well. Several analogues of huperzine A, compound 8, 10, 14, 15 and 17were prepared and their inhibitory activities of acetylcholinesterase were evaluated
