Synthesis of 1,4,6-tri-O-benzyl myo-inositol-A key intermediate to myo-inositol-1,2,5-O-trisphosphate

Synthesis of 1,4,6-tri-O-benzyl myo-inositol-A key intermediate to myo-inositol-1,2,5-O-trisphosphate

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摘要 A new synthetic approach to 1,4,6-tri-O-benzyl myo-inositol was described on the basis of the regioselective benzylation of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol, subsequent acid hydrolysis, phosphorylation with tetrabenazylpyrophosphate and appropriate deprotec-tion. A new synthetic approach to 1,4,6-tri-O-benzyl myo-inositol was described on the basis of the regioselective benzylation of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol, subsequent acid hydrolysis, phosphorylation with tetrabenazylpyrophosphate and appropriate deprotec-tion.

作者 YUAN, Cheng-Ye ZHAI, Hai-Xiao WENG, Guan-HongShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出处《Chinese Journal of Chemistry》 SCIE CAS CSCD 1994年第2期174-178,共5页 中国化学（英文版）

基金 Project supported by the National Natural Science Foundation of China。

关键词 MYO-INOSITOL synthesis regioselective benzylation. myo-Inositol, synthesis, regioselective benzylation.

分类号 O621 [理学—有机化学]

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Chinese Journal of Chemistry

1994年第2期

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Synthesis of 1,4,6-tri-O-benzyl myo-inositol-A key intermediate to myo-inositol-1,2,5-O-trisphosphate

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