体外循环患者红细胞膜流动性观察

OBSERVATION OF ERYTHROCYTE MEMBRANE FLUIDITY

对２５例心脏手术行体外循环患者转流期间红细胞膜流动性（ＬＦＵ）．血浆脂质过氧化物（ＬＰＯ）和红细胞超氧化物岐化酶（ＳＯＤ）动态变化进行观察．结果转流后期ＬＦＵ显著降低，ＬＰＯ显著升高．而ＳＯＤ活性转流初期升高明显，至转流２４小时恢复转流前水平，并且红细胞膜ＬＦＵ降低与血浆ＬＰＯ改变有显著负相关。提示，转流期间脂质过氧化增强．可能是红细胞膜流动性降低的原因之一。

Changes of erythrocyte membrane fluidity(LFU) and plasma lipid peroxidation(LPO) and SOD in erythrocyte were observed in 25 patients undergoing cardiopulmonary bypass (CP B) during heart operations and after CPB. The results indicate: the LPO was significantly increased and the LFU was greatly decreased at 60 min arter the start of CPB. During CPB the activity SOD in erythrocyte was significantly increased ,at 24 h the end of CPB, the activity returned to the level before CPB. The Decrease of LFU was correlated negatively with the level of LPO. this suggests that the increase of LPO might be one of the causes of the decrease of LFU in patients undergoing CPB and after CPB.