肺癌病人手术前后血清超氧化物歧化酶的动态研究

A Sequeutial Study on the Activity of Serum Superoxide Dismutase in Patients with Lung Cancer before and after Operation

本实验用邻苯酚法，对４６例肺癌，２５例良性胸部疾患病人进行手术前后血清ＳＯＤ活性的动态检测，并以１０５例健康人作对照。结果显示，肺癌病人术前ＳＯＤ活性明显低于良性胸部疾患病人和正常人，其降低的程度与肺癌的病期、原发肿瘤大小、淋巴结转移和组织学类型有密切关系。肺癌行根治术后，血清ＳＯＤ活性逐渐升高，术后２周可达正常水平。

The serial changes of the aetivity of serum superoxide dismutase(SOD) were detected by catechol method in 46 patients with lung cancer and 25 cases with noncancerous thoracic lesions before and after operation. One hundred and five healthy individuals were used as a control group.The SOD activity in cancer patients was significantly lower than that of noncancerous thoracic lesions and normal adults.The degrees of these changes were closely related to the stages of cancer,size of the primary tumor,presence of lymph mode metastasis and the type of histological classification.The activity inereased gradually and returned to normal level 2 weeks after removal of the tumor.