三种释放18甲基炔诺酮IUD的临床研究

A Comparative Study on 3 Kinds of Levonorgestrel Releasing IUDs and TCu_(22)C in 10 Medical Centers

４０００例健康育龄妇女接受三种ＬＮＧ－ＩＵＤ与ＴＣｕ２２０Ｃ作对照，每种ＩＵＤ各１０００例，随机分配至１０个中心进行比较性研究。钥匙形ＬＮＧ－ＩＵＤ的净累积续用率ＡＡＡＡ在三种ＬＮＧ－ＩＵＤ中最高（８６．４６％），但低于ＴＣｕ２２０Ｃ（９２．６８％）。宫外孕主要发生在钥匙形ＬＮＧ－ＩＵＤ，尤其在置器一年内。引起停用的主要原因，在ＬＮＧ－ＩＵＤ中为月经异常、点滴出血和／或闭经，而ＴＣｕ２２０Ｃ则为月经过多与腹痛。本文对四种ＩＵＤ的特点作了比较，提示三种ＬＮＧ－ＩＵＤ均具有较高的避孕效果，脱落率较低和月经失血量明显减少，给患有月经过多或痛经而需要用宫内节育器避孕的妇女使用比较适合。

From may 1988 through Jun 1990, 4000 healthy childbearing aged women were recruited in a study to compare the clinical results of 3 kinds of levonorgestrel releasing(LNG) IUDs(Key-shaped LNG-IUD 4μg/d, caltrop shaped LNG-IUD 15μg/d, Modified Nova-T -LNG=Cu IUD LNG- 10.8μg/d, Copper surface area 220mm2) with TCu220C as control. Each device was studied in 1000 cases. All were accepted by 10 medical centers. The investigation was carried out in a randomized manner. The net continuation rate of Key-shaped LNG-IUD was the highest (86.46%) within 3 LNG-IUDs but was lower that TCu220C (92.68%). Etopic pregnancy occurred mainly in Key-shaped LNG-IUD especially within 12 of insertion. In LNG-IUD cases abnormal menstrual bleeding, spotting and/or amenorrhea and in TCu220C cases hypermenorrhea and abdominal pain were the main causes of discontinuation. The characteristics of different kinds of IUD were compared. As a whole all these 3 LNG-IUDs showed a sufficiently high contraceptive efficacy, a lower expulsion rate and less menstrual blood loss. It is considered that all of these LNG-IUDs are suitabe for women suffering from dysmenorrhea or hypermenorrhea with a strong intention to use IUD.