实验性急性心肌梗塞左室功能改变的研究

Ventricular Function in Experimental Acute Myocardial Infarction

实验采用结扎羊心冠状动脉左前降支，建立急性心肌梗塞模型，并分别于结扎前，结扎即刻，结扎后１、２、３ｈ等五个阶段，运用二维和脉冲多普勒技术，测量反映左室收缩功能的系列指标，包括主动脉血流峰值速度（Ｖｐ）、主动脉血流加速度（ＡＣ）、左室收缩期容积（ＥＳＶ）、左室舒张末期容积（ＥＤＶ）和左室射血分数（ＥＦ）；以及反映左室舒张功能的系列指标，包括峰值速度Ｅ（ＰＥ）、峰值速度Ａ（ＰＡ）、面积Ｅ（ＳＥ）、面积Ａ（ＳＡ）、ＰＡ／ＰＥ以及ＳＡ／ＳＥ。实验发现反映左室收缩功能的各项指标发生显著或极显著的改变，说明这些指标对于急性心肌梗塞是敏感的。反映左室舒张功能的各项指标中，ＰＡ／ＰＥ、ＳＡ／ＳＥ、ＳＥ和ＰＥ发生显著或极显著的改变，是定量左室舒张功能较为可靠的指标。

A model of acute myocardial infarction was developed by ligating the anterior descending branch of left coronary artery (LAD). Using a 2-dimension and pulse-wave Doppler echocardiography, indices which reflected left ventricular systolic function were measured pre-occlusion, immediately after occlusion, and 1h, 2h, and 3h post-occlusion, including: VP,AC, ESV, EDV, EF, while indices which reflected left ventricular diastolic function were also mea sured, including: PE, PA, SE, SA, PA/PE, SA/SE. Results showed that parameters reflecting left ventricular function were significantly different between pre-and post-occlusion measurements. It suggrsted that these parameters were sensitive to AMI. Those parameters PA/PE, SA/SE, SE, PE changing markedly, could be used as reliable indices quantifying the left ventricular function.