摘要
本文研究了吡喹酮栓剂和片剂在家兔体内的药代动力学和栓剂的相对生物利用度。采用高效液相色谱法测试血药浓度，微机拟合药时曲线，服从一室开放模型。两制剂的消除半衰期[1/2值均小于2.5h。栓剂和片剂的吸收速率常数K_a别为2.64和1．45h^（-1）,具有显著差异（P＜0．001）。栓剂相对于片剂的生物利用度为187．7％。
In the present study the plasma concentration of praziquantel was determined with HPLC in rabbits.The pharmacokinetics and bioavailability of two preparations (suppos-itory and tablet )were studied.Both formulations were suited for one compartment open model by using iterative computer program LSNLR.The elimination half-life(t_1/2)was less than 2.5h,Rate constant of absorption (K_a)was significantly higher in suppository (2.64 h^(-1)than in tablet (1,45h^(-1)(P＜0.001.The relative bioavailability was 187.7%.Suppository was bettor than tablet in absorption-rate and extent.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
1994年第S2期93-95,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
