高血压与血瘀症

Essential Hypertension and Blood Stasis Syndrome

５３例高血压病人以有无血瘀症的临床表现分为血瘀型和非血瘀型二组，通过血液流变学、血脂、血小板聚集率、血浆纤维蛋白原、血栓素β２、前列环素、组织型纤溶酶激活物、纤溶酶抑制物和脂质过氧化物等检测，并与健康对照组作对照，发现血瘀型高血压除６－Ｋ－ＰＧＦ１α等个别指标外，血粘度明显升高，凝血指标显著增强，纤溶指标显著减弱，ＬＰＯ明显增多，差异有显著性（Ｐ＜０．０１或＜０．０５），揭示上述指标可作为高血压从非血瘀型转化成血瘀型的客观的佐证。

On the basis of major clinical manifestations of blood stasis syndrome,we divided 53 cases of essential hypertension into two groups, 34 of blood stasis type and 19 non stasis type. Hemoviscosity, blood lipids. PAgT, Fg, TXB2, 6-KPCF1α, t-PA, PAI and LPO were determined.A group of 16 normotensives matched with the same sex and age served as control.The outcome showed in blood stasis hypertensive’s most indice of blood viscosity,except a few in such as 6-KPGF1α were remarkably increased, coagulative indices rose,fibrinolytic activity decreased and LPO elevated suggesting that the above indices may provide a scientific evidence of the conclusion for discrimination of hypertension has transformed from non blood stasis type and blood stasis type. In the light of the relation of the indices, we discuss in this paper the pathogenesis of hypertension transformed from non-blood stasis type to blood stasis one and the action of blood stasis syndrome of traditional Chinese Medicine on diagnosis and treatment of essential hypertension.