Plasma Norepinephrine and Hemorheology in Essential Hypertensive Patients with Different Patterns of Left Ventricular Hypertrophy

对80例不同类型高血压左室肥厚（LVH）患者的血浆去甲肾上腺素（NE）和血液流变学改变进行观察。结果显示，（1）向心性肥厚组（CH）高切变率下全血粘度（WBV230）显著升高；（2）不对称性室间隔肥厚组（ASH）血浆NE和收缩末期室壁应力（ESS）增高较明显；（3）多元回归分析显示，SBP，ESS和血浆NE是影响相对室壁厚度的重要因素。提示CH是一种对压力负荷过重而产生的代偿形式；ASH的形成除了负荷因素外血浆NE可能起更重要的作用。

The changes in Plasma norepinepheinc (NE) andhenrorheolopy in 80 hyperbeive petients with different petterns ofleft ventricular hypertrophy (LVH) were studied. The results showedthat: (1) A higher value in whole blood viareity (WSV) at a shearrate of 230 was found in concentric hypertrophy (CH) group ascompered to the other groupe; (2) A significant increase in plasmaNE and end cystolic wall stress (ESS) was found in asymmetric sep-tal hypertrophy (ASH ) group; (3) Multiple stepwise regressionanalysis revealed that SBP, ESS and plasma NE were the theee impor-tant factere affecting the relative left ventricular wall thicaness. Theauthors suggest that CH appear to be a compensated state adapted tothe increase in afterload. Significant incrun in plasma NE concen-tration in ASH gIoup indicated once more the important role of theincreased adeenergic activity on the development of ASH besides theafterload factor.