维甲酸并化疗治疗急性早幼粒细胞白血病

Retinoic Acid Following Chemotherapy for22 Patients with Acute Promyelocytic Leukemia

对２２例急性早幼粒细胞白血病（ＡＰＬ）患者单用全反式维甲酸（ＡＴＲＡ）进行诱导缓解，２０例（９０．９％）达到完全缓解（ＣＲ），平均时间４２天。２０例白细胞升高，平均２６．４４×１０~９／Ｌ白细胞升到最高值所需时间中位数为１１天。ＣＲ后用阿糖胞苷、阿霉素、三尖杉进行２个疗程的巩固化疗。ＡＴＲＡ的副作用包括皮肤粘膜干燥、头痛、骨骼肌肉酸痛等，患者一般能耐受。

Patients with newly diagnosecl acute promyelocytic leukemia(APL)were scheduled to receive all-transretinoid acid(ATRA)80 mg/d until complete remission(CR),followed by two intensive daunortibicin+AraC+Horritonire courses(″3+7+7″course).Twenty patients(90.9)achieved CR,Two patients died on day 3 and day 4,from lung failure and CNS bleeding respectively.The result suggest that intensive maintenace chemotherapy may reduce the relapse rate and prolong disease free interval.Side effects were usually moderate.