抗白细胞CD18单克隆抗体在脑缺血损伤中的保护作用──动物实验研究

Protective effect of monoclonal antibody to leukocyte CD_(18) on cerebral lschcmia:animal experimental study

本文用光诱导局部血栓形成动物模型，观察了抗白细胞ＣＤ１８单克隆抗体在脑缺血损伤中的保护作用。研究结果表明，抗白细胞ＣＤ１８单克隆抗体可显著缩小梗塞面积，减轻脑梗塞后的神经功能缺失状况，提示抑制白细胞粘附介导的缺血损伤是防治脑梗塞的一种新途径。

The protective effect of monoclonal antibody to leukocyte CD_18(MoAL CD_18)was observed in an animal model of local cerebral vascular thrombosis induced photochemically.The results demonstrated that the MoAL CD_18 could decrease the size of ceredral infarct areas and improve the neurological functional disabilities significantly.It implied that inhibiting the adherence of Leukocyte could be an alternate way to treat and prevent the cerebral ischemic damage.